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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Hi Albert,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">If you have the coordinates of the sternum in both fixed and moving image you can add a term to the registration framework that penalizes deviation away from
alignment of that point (or multiple points). We have done something similar:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><a href="http://elastix.isi.uu.nl/marius/publications/2011_c_MICCAIb.html">http://elastix.isi.uu.nl/marius/publications/2011_c_MICCAIb.html</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">code of which can be found in elastix, which you can use freely.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">But it all depends on whether you have corresponding pointsets.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Marius<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-left:36.0pt"><b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif"">From:</span></b><span style="font-size:10.0pt;font-family:"Tahoma","sans-serif""> insight-users-bounces@itk.org [mailto:insight-users-bounces@itk.org]
<b>On Behalf Of </b>Albert Gubern Mérida<br>
<b>Sent:</b> maandag 25 juli 2011 15:41<br>
<b>To:</b> insight-users@itk.org<br>
<b>Subject:</b> [Insight-users] B-Splines registration with fixed points<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
<p class="MsoNormal" style="margin-left:36.0pt">Hi all,<o:p></o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt">I am currently working in Breast MRI registration between different patients, especially interested in the alignment of body area (thorax + pectoral muscles). The first step of my registration consist of a translation
to align the sternum, which gives a good initial alignment of the pectoral muscles. In the following link you can see an example of one slice with the sternum indicated with a white cross: <a href="http://imageshack.us/photo/my-images/220/breastmristernum.png/">http://imageshack.us/photo/my-images/220/breastmristernum.png/</a>. After
the translation step with the pectorals already "rigidly" aligned I apply non-rigid b-splines registration to the whole volumes. It works well in some cases, but in others, especially of course when the differences are high between fixed and moving images,
the non-rigid registration move the sternum point and the pectorals are not aligned anymore. <o:p></o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt">I have thought that not allowing the non-registration the move of the sternum point and the ones close to it could be a good solution for such problem. However, I have taken a look to the classes and the mailing
list but I have not found any direct/easy example to how to do that. <o:p></o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt">Could anyone give me some advice? Does a easy way to do it exist or I should modify the classes involved in the registration framework? Which ones should I take a look? <o:p></o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt">Thanks in advance,<o:p></o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt"><o:p> </o:p></p>
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<p class="MsoNormal" style="margin-left:36.0pt">Albert<o:p></o:p></p>
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